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Article

CYP2D6 polymorphism and clinical effect of the antidepressant venlafaxine.

Journal of clinical pharmacy and therapeutics - 1 Oct 2006

Shams M E E, Arneth B, Hiemke C, Dragicevic A, Müller M J, Kaiser R, Lackner K, Härtter S

Abstract excerpt

BACKGROUND: Venlafaxine (V) is a mixed serotonin and noradrenaline reuptake inhibitor used as a first-line treatment of depressive disorders. It is metabolized primarily by the highly polymorphic cytochrome P450 (CYP) enzyme CYP2D6 to yield a pharmacologically active metabolite, O-desmethylvenlafaxine (ODV), and to a lesser extent by CYP3A4, to yield N-desmethylvenlafaxine (NDV). OBJECTIVES: The aim of this study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16958828
DOI: 10.1111/j.1365-2710.2006.00763.x

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