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Article

Role of CYP2D6 in the stereoselective disposition of venlafaxine in humans.

Pharmacogenetics - 1 Jan 2003

Eap Chin B, Lessard Etienne, Baumann Pierre, Brawand-Amey Marlyse, Yessine Marie-Andrée, O'Hara Gilles, Turgeon Jacques

Abstract excerpt

CYP2D6 is involved in the O-demethylation metabolic pathway of venlafaxine in humans. In this study, we investigated whether this isozyme is stereoselective. Plasma samples from seven CYP2D6 extensive metabolizers (EMs) and five CYP2D6 poor metabolizers (PMs), collected during a period without and with coadministration of quinidine, were analysed. Subjects were administered venlafaxine hydrochloride 18.75 mg...

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Identifiers

PMID: 12544511
DOI: 10.1097/00008571-200301000-00006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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