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Article

A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida.

Developmental cell - 1 Aug 2007

Rui Yanning, Xu Zhen, Xiong Bo, Cao Ying, Lin Shuyong, Zhang Min, Chan Siu-Chiu, Luo Wen, Han Ying, Lu Zailian, Ye Zhiyun, Zhou Hai-Meng, Han Jiahuai, Meng Anming, Lin Sheng-Cai

Abstract excerpt

Axin is a scaffold protein that controls multiple important pathways, including the canonical Wnt pathway and JNK signaling. Here we have identified an Axin-interacting protein, Aida, which blocks Axin-mediated JNK activation by disrupting Axin homodimerization. During investigation of in vivo functions of Axin/JNK signaling and aida in development, it was found that Axin, besides ventralizing activity by...

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Identifiers

PMID: 17681137
DOI: 10.1016/j.devcel.2007.07.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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