Article
Downregulation of Jun kinase signaling in the amnioserosa is essential for dorsal closure of the Drosophila embryo.
Current biology : CB - 24 Jul 2001
Reed B H, Wilk R, Lipshitz H D
Abstract excerpt
BACKGROUND: During Drosophila embryogenesis, Jun kinase (JNK) signaling has been shown to play a key role in regulating the morphogenetic process of dorsal closure, which also serves as a model for epithelial sheet fusion during wound repair. During dorsal closure the JNK signaling cascade in the dorsal-most (leading edge) cells of the epidermis activates the AP-1 transcription factor comprised of DJUN and DFOS...
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