Article
Axin-induced apoptosis depends on the extent of its JNK activation and its ability to down-regulate beta-catenin levels.
Biochemical and biophysical research communications - 27 May 2000
Neo S Y, Zhang Y, Yaw L P, Li P, Lin S C
Abstract excerpt
Axin is a multidomain protein that coordinates a variety of critical factors in Wnt signaling and JNK activation. In this study, we found that overexpression of Axin leads to apoptosis in several cell lines. A mutant Axin (Axin-deltaMID) that does not contain the MEKK1-interacting domain and is not capable of activating JNK, has less apoptotic effect. Together with the observations that dominant-negative forms of...
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