Article
ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling.
Nature communications - 12 Jun 2020
Sun Xiaoyun, Peng Xixia, Cao Yuqin, Zhou Yan, Sun Yuhua
Abstract excerpt
ADNP (Activity Dependent Neuroprotective Protein) is a neuroprotective protein whose aberrant expression has been frequently linked to neural developmental disorders, including the Helsmoortel-Van der Aa syndrome (also called the ADNP syndrome). However, its role in neural development and pathology remains unclear. Here, we show that ADNP is required for neural induction and differentiation by enhancing Wnt...
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