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Article

Negative regulation of Smad2 by PIASy is required for proper Xenopus mesoderm formation.

Development (Cambridge, England) - 1 Nov 2004

Daniels Maki, Shimizu Kazuya, Zorn Aaron M, Ohnuma Shin-ichi

Abstract excerpt

Mesoderm induction and patterning are primarily regulated by the concentration of locally expressed morphogens such as members of the TGFbetasuperfamily. Smad2 functions as a transcription factor to regulate expression of mesodermal genes downstream of such morphogens. We have identified Xenopus PIASy (XPIASy), a member of the PIAS family, by yeast two-hybrid screening using Xenopus Smad2 (XSmad2) as a bait....

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Identifiers

PMID: 15496439
DOI: 10.1242/dev.01449

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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