Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin.

Science (New York, N.Y.) - 12 Mar 1999

Hamada F, Tomoyasu Y, Takatsu Y, Nakamura M, Nagai S, Suzuki A, Fujita F, Shibuya H, Toyoshima K, Ueno N, Akiyama T

Abstract excerpt

Wnt/Wingless directs many cell fates during development. Wnt/Wingless signaling increases the amount of beta-catenin/Armadillo, which in turn activates gene transcription. Here the Drosophila protein D-Axin was shown to interact with Armadillo and D-APC. Mutation of d-axin resulted in the accumul...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenomatous Polyposis Coli Protein
Share to Armadillo Domain Proteins
Share to Axin Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Body Patterning

Share to Extremities

Share to Insect Proteins

Share to Wings, Animal

Share to Wnt1 Protein

Source

Identifiers

PMID: 10073940
DOI: 10.1126/science.283.5408.1739

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10073940-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin.PMID 10073940Read ↗

Biochemical characterization of the Drosophila axin protein.Semantic proximity Read ↗

A screen for mutations that suppress the phenotype of Drosophila armadillo, the beta-catenin homolog.Semantic proximity Read ↗

The links between axin and carcinogenesisSemantic proximity Read ↗

Roles of the C terminus of Armadillo in Wingless signaling in Drosophila.Semantic proximity Read ↗

A screen for identifying genes interacting with armadillo, the Drosophila homolog of beta-catenin.Semantic proximity Read ↗

Wnt/Wingless Pathway Activation Is Promoted by a Critical Threshold of Axin Maintained by the Tumor Suppressor APC and the ADP-Ribose Polymerase Tankyrase.Semantic proximity Read ↗

Loss of Nkd1 is epistatic to loss of Axin2 in regulating Wnt signalingSemantic proximity Read ↗

The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled.Semantic proximity Read ↗

Nkd1 functions downstream of Axin2 to attenuate Wnt signaling.Semantic proximity Read ↗

Unexpectedly robust assembly of the Axin destruction complex regulates Wnt/Wg signaling in Drosophila as revealed by analysis in vivo.Semantic proximity Read ↗

Drosophila Wnt/Fz pathways.Semantic proximity Read ↗

Roles of Armadillo, a Drosophila catenin, during central nervous system development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.