Article
An alternatively spliced, non-signaling insulin receptor modulates insulin sensitivity via insulin peptide sequestration in C. elegans.
eLife - 25 Feb 2020
Martinez Bryan A, Reis Rodrigues Pedro, Nuñez Medina Ricardo M, Mondal Prosenjit, Harrison Neale J, Lone Museer A, Webster Amanda, Gurkar Aditi U, Grill Brock, Gill Matthew S
Abstract excerpt
In the nematode C. elegans, insulin signaling regulates development and aging in response to the secretion of numerous insulin peptides. Here, we describe a novel, non-signaling isoform of the nematode insulin receptor (IR), DAF-2B, that modulates insulin signaling by sequestration of insulin peptides. DAF-2B arises via alternative splicing and retains the extracellular ligand binding domain but lacks the...
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