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Article

Partitioning of the truncated insulin receptor DAF-2B between homodimers and heterodimers influences insulin signaling in C. elegans.

PLoS genetics - 1 Jul 2026

Martinez Bryan A, Stene Anne M, Hauser Jonathan I, Opperman Karla J, Sachs Jonathan N, Braun Anthony R, Gill Matthew S

Abstract excerpt

Insulin / insulin-like growth factor signaling (IIS) in C. elegans is mediated by the DAF-2 receptor and insulin-like peptides (ILP) that can act as agonists or antagonists. DAF-2 signaling is also affected by DAF-2B, a truncated, non-signaling, secreted isoform of DAF-2 that acts as a decoy receptor by sequestering ILPs. In this study, we performed a forward genetic screen for modifiers of DAF-2B protein...

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Identifiers

PMID: 42490665
DOI: 10.1371/journal.pgen.1012240
PMCID: PMC13421766

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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