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LINC, a Human Complex That is Related to pRB-Containing Complexes in Invertebrates Regulates the Expression of G<sub>2</sub>/M Genes

1 Aug 2007

Abstract excerpt

Here we report the identification of the LIN complex (LINC), a human multiprotein complex that is required for transcriptional activation of G2/M genes. LINC is related to the recently identified dREAM and DRM complexes of Drosophila and C. elegans that contain homologs of the mammalian retinoblastoma tumor suppressor protein. The LINC core complex consists of at least five subunits including the...

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PMID: 17671431
DOI: 10.4161/cc.6.15.4512

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