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Article

Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence.

Molecular cell - 25 May 2007

Litovchick Larisa, Sadasivam Subhashini, Florens Laurence, Zhu Xiaopeng, Swanson Selene K, Velmurugan Soundarapandian, Chen Runsheng, Washburn Michael P, Liu X Shirley, DeCaprio James A

Abstract excerpt

The mammalian Retinoblastoma (RB) family including pRB, p107, and p130 represses E2F target genes through mechanisms that are not fully understood. In D. melanogaster, RB-dependent repression is mediated in part by the multisubunit protein complex Drosophila RBF, E2F, and Myb (dREAM) that contains homologs of the C. elegans synthetic multivulva class B (synMuvB) gene products. Using an integrated approach...

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Share to Caenorhabditis elegans
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17531812
DOI: 10.1016/j.molcel.2007.04.015

Genes

MYB
RBBP4
RBL2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence.PMID 17531812Read ↗

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