Article
Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans.
American journal of human genetics - 1 Jan 2004
Oksenberg Jorge R, Barcellos Lisa F, Cree Bruce A C, Baranzini Sergio E, Bugawan Teodorica L, Khan Omar, Lincoln Robin R, Swerdlin Amy, Mignot Emmanuel, Lin Ling, Goodin Douglas, Erlich Henry A, Schmidt Silke, Thomson Glenys, Reich David E, Pericak-Vance Margaret A, Haines Jonathan L, Hauser Stephen L
Abstract excerpt
An underlying complex genetic susceptibility exists in multiple sclerosis (MS), and an association with the HLA-DRB1*1501-DQB1*0602 haplotype has been repeatedly demonstrated in high-risk (northern European) populations. It is unknown whether the effect is explained by the HLA-DRB1 or the HLA-DQB1 gene within the susceptibility haplotype, which are in strong linkage disequilibrium (LD). African populations are...
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