Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HLA‐DRB1*15:01 is a co‐receptor for Epstein–Barr virus, linking genetic and environmental risk factors for multiple sclerosis

21 May 2021

Abstract excerpt

The strongest genetic and environmental risk factors for MS, an inflammatory CNS disease, are HLA-DRB1*15:01 and EBV. This work shows that HLA-DRB1*15:01 acts as a co-receptor for EBV infection of a B cell line, suggesting a mechanistic link between both risk factors for MS.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Cell Function and Interaction
Share to Multiple Sclerosis Research Studies
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34019695
DOI: 10.1002/eji.202149179

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HLA‐DRB1*15:01 is a co‐receptor for Epstein–Barr virus, linking genetic and environmental risk factors for multiple sclerosisPMID 34019695Read ↗

HLA-A confers an HLA-DRB1 independent influence on the risk of multiple sclerosis.Semantic proximity Read ↗

Integrating risk factors: HLA-DRB1*1501 and Epstein-Barr virus in multiple sclerosis.Semantic proximity Read ↗

The Multiple Sclerosis (MS) Genetic Risk Factors Indicate both Acquired and Innate Immune Cell Subsets Contribute to MS Pathogenesis and Identify Novel Therapeutic OpportunitiesSemantic proximity Read ↗

DRB1-environment interactions in multiple sclerosis etiology: results from two Swedish case-control studies.Semantic proximity Read ↗

Epstein Barr Virus Exploits Genetic Susceptibility to Increase Multiple Sclerosis RiskSemantic proximity Read ↗

Class II HLA (DRB1, & DQB1) alleles and IL7R (rs6897932) variants and the risk for Multiple Sclerosis in Kerala, India.Semantic proximity Read ↗

The interaction between Epstein–Barr virus and multiple sclerosis genetic risk loci: insights into disease pathogenesis and therapeutic opportunitiesSemantic proximity Read ↗

Systematic review and meta-analysis of the association between Epstein-Barr virus, Multiple Sclerosis, and other risk factorsSemantic proximity Read ↗

Immunogenetic Epidemiology of Multiple Sclerosis in 14 Continental Western European CountriesSemantic proximity Read ↗

Vitamin D receptor (VDR) gene SNPs influence VDR expression and modulate protection from multiple sclerosis in HLA-DRB1*15-positive individuals.Semantic proximity Read ↗

Stratifying Multiple Sclerosis Susceptibility Risk: The Role of HLA-E*01 and Infectious Mononucleosis in a Population Cohort.Semantic proximity Read ↗

High resolution HLA analysis reveals independent class I haplotypes and amino-acid motifs protective for multiple sclerosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.