Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An active Src kinase-beta-actin association is linked to actin dynamics at the periphery of colon cancer cells.

Experimental cell research - 10 Sept 2007

Avizienyte Egle, Keppler Melanie, Sandilands Emma, Brunton Valerie G, Winder Steve J, Ng Tony, Frame Margaret C

Abstract excerpt

Src controls the dynamic actin cytoskeleton in fibroblasts and in cancer cells, although it is not known how direct its effects are. Using FRET/FLIM imaging, we found that wild type Src associates directly, or indirectly, with peripheral beta-actin at integrin adhesions after serum stimulation, and that an active Src kinase domain is essential. Beta-actin can be directly tyrosine-phosphorylated by Src in vitro,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Cell Communication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colonic Neoplasms

Share to Cytoskeletal Proteins

Share to Cytoskeleton

Share to Fluorescence Resonance Energy Transfer

Share to src-Family Kinases

Share to src Homology Domains

Source

Identifiers

PMID: 17651734
DOI: 10.1016/j.yexcr.2007.04.037

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An active Src kinase-beta-actin association is linked to actin dynamics at the periphery of colon cancer cells.PMID 17651734Read ↗

A FAK/Src chimera with gain-of-function properties promotes formation of large peripheral adhesions associated with dynamic actin assembly.Semantic proximity Read ↗

The SRC-induced mesenchymal state in late-stage colon cancer cells.Semantic proximity Read ↗

Epidermal growth factor-induced activation and translocation of c-Src to the cytoskeleton depends on the actin binding domain of the EGF-receptor.Semantic proximity Read ↗

Activation of the actin/MRTF-A/SRF signalling pathway in pre-malignant mammary epithelial cells by P-cadherin is essential for transformationSemantic proximity Read ↗

Src kinase modulates the activation, transport and signalling dynamics of fibroblast growth factor receptors.Semantic proximity Read ↗

Dissecting motility signaling through activation of specific Src-effector complexes.Semantic proximity Read ↗

Dynamics and mechanism of p130Cas localization to focal adhesions.Semantic proximity Read ↗

Mimicking transient activation of protein kinases in living cells.Semantic proximity Read ↗

Engineered kinase activation reveals unique morphodynamic phenotypes and associated trafficking for Src family isoforms.Semantic proximity Read ↗

Tyrosine phosphorylation within the SH3 domain regulates CAS subcellular localization, cell migration, and invasiveness.Semantic proximity Read ↗

Src42A required for collective border cell migration <i>in vivo</i>Semantic proximity Read ↗

Individual Cas phosphorylation sites are dispensable for processive phosphorylation by Src and anchorage-independent cell growth.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.