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Article

The SRC-induced mesenchymal state in late-stage colon cancer cells.

Cells, tissues, organs - 1 Jan 2005

Avizienyte Egle, Brunton Valerie G, Fincham Valerie J, Frame Margaret C

Abstract excerpt

One major function of elevated Src kinase in epithelial cancer cells is to drive adhesion changes that are associated with the mesenchymal transition and metastasis. Here we review recent work that describes Src-induced shape changes, and the mechanisms involved, in cells derived from a model of colon cancer metastasis. Src activity in these cells is associated with formation and dynamic regulation of integrin...

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Source

Identifiers

PMID: 15942195
DOI: 10.1159/000084511

Genes

SRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The SRC-induced mesenchymal state in late-stage colon cancer cells.PMID 15942195Read ↗

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An active Src kinase-beta-actin association is linked to actin dynamics at the periphery of colon cancer cells.Semantic proximity Read ↗

Activation of c-Src by receptor tyrosine kinases in human colon cancer cells with high metastatic potential.Semantic proximity Read ↗

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