Article
Engineered kinase activation reveals unique morphodynamic phenotypes and associated trafficking for Src family isoforms.
Proceedings of the National Academy of Sciences of the United States of America - 26 Aug 2014
Chu Pei-Hsuan, Tsygankov Denis, Berginski Matthew E, Dagliyan Onur, Gomez Shawn M, Elston Timothy C, Karginov Andrei V, Hahn Klaus M
Abstract excerpt
The Src kinase family comprises nine homologous members whose distinct expression patterns and cellular distributions indicate that they have unique roles. These roles have not been determined because genetic manipulation has not produced clearly distinct phenotypes, and the kinases' homology complicates generation of specific inhibitors. Through insertion of a modified FK506 binding protein (insertable FKBP12,...
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