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Article

Dynamics and mechanism of p130Cas localization to focal adhesions.

The Journal of biological chemistry - 2 Jul 2010

Donato Dominique M, Ryzhova Larisa M, Meenderink Leslie M, Kaverina Irina, Hanks Steven K

Abstract excerpt

The docking protein p130Cas is a major Src substrate involved in integrin signaling and mechanotransduction. Tyrosine phosphorylation of p130Cas in focal adhesions (FAs) has been linked to enhanced cell migration, invasion, proliferation, and survival. However, the mechanism of p130Cas targeting to FAs is uncertain, and dynamic aspects of its localization have not been explored. Using live cell microscopy, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20430882
DOI: 10.1074/jbc.M109.091207
PMCID: PMC2898362

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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