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Article

Dissecting motility signaling through activation of specific Src-effector complexes.

Nature chemical biology - 1 Apr 2014

Karginov Andrei V, Tsygankov Denis, Berginski Matthew, Chu Pei-Hsuan, Trudeau Evan D, Yi Jason J, Gomez Shawn, Elston Timothy C, Hahn Klaus M

Abstract excerpt

We describe an approach to selectively activate a kinase in a specific protein complex or at a specific subcellular location within living cells and within minutes. This reveals the effects of specific kinase pathways without time for genetic compensation. The new technique, dubbed rapamycin-regulated targeted activation of pathways (RapRTAP), was used to dissect the role of Src kinase interactions with FAK and...

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Identifiers

PMID: 24609359
DOI: 10.1038/nchembio.1477
PMCID: PMC4064790

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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