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Article

Src kinase modulates the activation, transport and signalling dynamics of fibroblast growth factor receptors.

EMBO reports - 1 Dec 2007

Sandilands Emma, Akbarzadeh Shiva, Vecchione Anna, McEwan David G, Frame Margaret C, Heath John K

Abstract excerpt

The non-receptor tyrosine kinase Src is recruited to activated fibroblast growth factor receptor (FGFR) complexes through the adaptor protein factor receptor substrate 2 (FRS2). Here, we show that Src kinase activity has a crucial role in the regulation of FGFR1 signalling dynamics. Following receptor activation by ligand binding, activated Src is colocalized with activated FGFR1 at the plasma membrane. This...

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Source

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Identifiers

PMID: 17975556
DOI: 10.1038/sj.embor.7401097
PMCID: PMC2267225

Genes

FGFR1
FRS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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