Article

Activation of the actin/MRTF-A/SRF signalling pathway in pre-malignant mammary epithelial cells by P-cadherin is essential for transformation

2022-02-27

Abstract excerpt

Alterations in the expression or function of cell adhesion molecules have been implicated in all steps of tumour progression. Among those, P-cadherin expression is highly enriched in basal-like breast cancer, a molecular subset of triple-negative breast carcinomas, playing a central role in inducing cancer cell self-renewal, as well as collective cell migration and invasion capacity. To decipher the P-cadherin-dep...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e3248b0c-03e6-5114-b13a-b9ccf3958ce6
DOI: 10.1101/2022.02.26.481995

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Activation of the actin/MRTF-A/SRF signalling pathway in pre-malignant mammary epithelial cells by P-cadherin is essential for transformationDOI 10.1101/2022.02.26.481995Read

Src family kinases, adaptor proteins and the actin cytoskeleton in epithelial-to-mesenchymal transitionSemantic proximity Read

mDia2 is an important mediator of MRTF-A-dependent regulation of breast cancer cell migrationSemantic proximity Read

RASSF1C oncogene elicits amoeboid invasion, cancer stemness and invasive EVs via a novel SRC/Rho axisSemantic proximity Read

RhoC: a fascinating journey from a cytoskeletal organizer to a Cancer stem cell therapeutic targetSemantic proximity Read

The WISP1/Src/MIF Axis Promotes the Malignant Phenotype of Non-Invasive Breast Cancer CellsSemantic proximity Read

Role of Rho-family proteins in cell adhesion and cancer.Semantic proximity Read

The WISP1/Src/MIF Axis Promotes the Malignant Phenotype of Non-Invasive MCF7 Breast Cancer Cells.Semantic proximity Read

ShcA signalling is essential for tumour progression in mouse models of human breast cancerSemantic proximity Read

The transcriptional programme of contact‐inhibitionSemantic proximity Read

Epithelial Protein Lost in Neoplasm alpha (Eplin-alpha) is transcriptionally regulated by G-actin and MAL/MRTF coactivators.Semantic proximity Read

RAC1 GTP-ase signals Wnt-beta-catenin pathway mediated integrin-directed metastasis-associated tumor cell phenotypes in triple negative breast cancers.Semantic proximity Read