Article
A FAK/Src chimera with gain-of-function properties promotes formation of large peripheral adhesions associated with dynamic actin assembly.
Cell motility and the cytoskeleton - 1 Jan 2008
Siesser Priscila M F, Meenderink Leslie M, Ryzhova Larisa, Michael Kristin E, Dumbauld David W, García Andrés J, Kaverina Irina, Hanks Steven K
Abstract excerpt
Formation of a complex between the tyrosine kinases FAK and Src is a key integrin-mediated signaling event implicated in cell motility, survival, and proliferation. Past studies indicate that FAK functions in the complex primarily as a "scaffold," acting to recruit and activate Src within cell/matrix adhesions. To study the cellular impact of FAK-associated Src signaling we developed a novel gain-of-function...
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