Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions.

doi:10.1038/ng2099

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Article

Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions.

Nature genetics - 1 Aug 2007

Winkelmann Juliane, Schormair Barbara, Lichtner Peter, Ripke Stephan, Xiong Lan, Jalilzadeh Shapour, Fulda Stephany, Pütz Benno, Eckstein Gertrud, Hauk Stephanie, Trenkwalder Claudia, Zimprich Alexander, Stiasny-Kolster Karin, Oertel Wolfgang, Bachmann Cornelius G, Paulus Walter, Peglau Ines, Eisensehr Ilonka, Montplaisir Jacques, Turecki Gustavo, Rouleau Guy, Gieger Christian, Illig Thomas, Wichmann H-Erich, Holsboer Florian, Müller-Myhsok Bertram, Meitinger Thomas

Abstract excerpt

Restless legs syndrome (RLS) is a frequent neurological disorder characterized by an imperative urge to move the legs during night, unpleasant sensation in the lower limbs, disturbed sleep and increased cardiovascular morbidity. In a genome-wide association study we found highly significant associations between RLS and intronic variants in the homeobox gene MEIS1, the BTBD9 gene encoding a BTB(POZ) domain as well...

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Identifiers

PMID: 17637780
DOI: 10.1038/ng2099

Genes

MEIS1
BTBD9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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