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Article

MEIS1 intronic risk haplotype associated with restless legs syndrome affects its mRNA and protein expression levels.

Human molecular genetics - 15 Mar 2009

Xiong Lan, Catoire Hélène, Dion Patrick, Gaspar Claudia, Lafrenière Ronald G, Girard Simon L, Levchenko Anastasia, Rivière Jean-Baptiste, Fiori Laura, St-Onge Judith, Bachand Isabelle, Thibodeau Pascale, Allen Richard, Earley Christopher, Turecki Gustavo, Montplaisir Jacques, Rouleau Guy A

Abstract excerpt

Restless legs syndrome (RLS) is a common neurological disorder characterized by an irresistible urge to move the legs at night, which is often accompanied by unpleasant sensations. A recent genomewide association study identified an association between RLS and intronic markers from the MEIS1 gene. Comparative genomic analysis indicates that MEIS1 is the only gene encompassed in this evolutionarily conserved...

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Identifiers

PMID: 19126776
DOI: 10.1093/hmg/ddn443
PMCID: PMC2722232

Genes

MEIS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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