Article
Association studies of variants in MEIS1, BTBD9, and MAP2K5/SKOR1 with restless legs syndrome in a US population.
Sleep medicine - 1 Sept 2011
Yang Qinbo, Li Lin, Chen Qiuyun, Foldvary-Schaefer Nancy, Ondo William G, Wang Qing Kenneth
Abstract excerpt
BACKGROUND: A genome-wide association study (GWAS) identified significant association between variants in MEIS1, BTBD9, and MAP2K5/SKOR1 and restless legs syndrome (RLS). However, many independent replication studies are needed to unequivocally establish a valid genotype-phenotype association across various populations. To further validate the GWAS findings, we investigated three variants, rs2300478 in MEIS1,...
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