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Predicting BRCA1 and BRCA2 gene mutation carriers: comparison of LAMBDA, BRCAPRO, Myriad II, and modified Couch models.

Familial cancer - 1 Jan 2007

Lindor Noralane M, Lindor Rachel A, Apicella Carmel, Dowty James G, Ashley Amanda, Hunt Katherine, Mincey Betty A, Wilson Marcia, Smith M Cathie, Hopper John L

Abstract excerpt

CONTEXT: Models have been developed to predict the probability that a person carries a detectable germline mutation in the BRCA1 or BRCA2 genes. Their relative performance in a clinical setting is unclear. OBJECTIVE: To compare the performance characteristics of four BRCA1/BRCA2 gene mutation prediction models: LAMBDA, based on a checklist and scores developed from data on Ashkenazi Jewish (AJ) women; BRCAPRO, a...

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Identifiers

PMID: 17636425
DOI: 10.1007/s10689-007-9150-z
PMCID: PMC2933048

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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