Article
Validity of models for predicting BRCA1 and BRCA2 mutations.
Annals of internal medicine - 2 Oct 2007
Parmigiani Giovanni, Chen Sining, Iversen Edwin S, Friebel Tara M, Finkelstein Dianne M, Anton-Culver Hoda, Ziogas Argyrios, Weber Barbara L, Eisen Andrea, Malone Kathleen E, Daling Janet R, Hsu Li, Ostrander Elaine A, Peterson Leif E, Schildkraut Joellen M, Isaacs Claudine, Corio Camille, Leondaridis Leoni, Tomlinson Gail, Amos Christopher I, Strong Louise C, Berry Donald A, Weitzel Jeffrey N, Sand Sharon, Dutson Debra, Kerber Rich, Peshkin Beth N, Euhus David M
Abstract excerpt
BACKGROUND: Deleterious mutations of the BRCA1 and BRCA2 genes confer susceptibility to breast and ovarian cancer. At least 7 models for estimating the probabilities of having a mutation are used widely in clinical and scientific activities; however, the merits and limitations of these models are not fully understood. OBJECTIVE: To systematically quantify the accuracy of the following publicly available models to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.