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Article

Accuracy of BRCA1/2 mutation prediction models for different ethnicities and genders: experience in a southern Chinese cohort.

World journal of surgery - 1 Apr 2012

Kwong Ava, Wong Connie H N, Suen Dacita T K, Co Michael, Kurian Allison W, West Dee W, Ford James M

Abstract excerpt

BACKGROUND: BRCA1/2 mutation prediction models (BRCAPRO, Myriad II, Couch, Shattuck-Eidens, BOADICEA) are well established in western cohorts to estimate the probability of BRCA1/2 mutations. Results are conflicting in Asian populations. Most studies did not account for gender-specific prediction. We evaluated the performance of these models in a Chinese cohort, including males, before BRCA1/2 mutation testing....

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Source

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Identifiers

PMID: 22290208
DOI: 10.1007/s00268-011-1406-y
PMCID: PMC3299960

Genes

BRCA1

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