Article
Performance of BRCA1/2 mutation prediction models in male breast cancer patients.
Clinical genetics - 1 Jan 2018
Moghadasi S, Grundeken V, Janssen L A M, Dijkstra N H, Rodríguez-Girondo M, van Zelst-Stams W A G, Oosterwijk J C, Ausems M G E M, Oldenburg R A, Adank M A, Blom E W, Ruijs M W G, van Os T A M, van Deurzen C H M, Martens J W M, Schroder C P, Wijnen J T, Vreeswijk M P G, van Asperen C J
Abstract excerpt
To establish whether existing mutation prediction models can identify which male breast cancer (MBC) patients should be offered BRCA1 and BRCA2 diagnostic DNA screening, we compared the performance of BOADICEA (Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm), BRCAPRO (BRCA probability) and the Myriad prevalence table ("Myriad"). These models were evaluated using the family data...
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