Article
Validation study of the LAMBDA model for predicting the BRCA1 or BRCA2 mutation carrier status of North American Ashkenazi Jewish women.
Clinical genetics - 1 Aug 2007
Apicella C, Dowty J G, Dite G S, Jenkins M A, Senie R T, Daly M B, Andrulis I L, John E M, Buys S S, Li F P, Glendon G, Chung W, Ozcelik H, Miron A, Kotar K, Southey M C, Foulkes W D, Hopper J L
Abstract excerpt
LAMBDA is a model that estimates the probability an Ashkenazi Jewish (AJ) woman carries an ancestral BRCA1 or BRCA2 mutation from her personal and family cancer history. LAMBDA is relevant to clinical practice, and its implementation does not require a computer. It was developed principally from Australian and UK data. We conducted a validation study using 1286 North American AJ women tested for the mutations...
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