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Article

Immunosuppression via tryptophan catabolism: the role of kynurenine pathway enzymes.

Transplantation - 15 Jul 2007

Belladonna Maria Laura, Puccetti Paolo, Orabona Ciriana, Fallarino Francesca, Vacca Carmine, Volpi Claudia, Gizzi Stefania, Pallotta Maria Teresa, Fioretti Maria Cristina, Grohmann Ursula

Abstract excerpt

Tryptophan catabolism occurring in dendritic cells (DCs) and initiated by indoleamine 2,3-dioxygenase (IDO) is an emerging major mechanism of peripheral tolerance. Here we provide evidence that: 1) tryptophan conversion to kynurenines is activated in DCs by cytotoxic T lymphocyte antigen 4, both in a soluble form or anchored to the regulatory T cell (Treg) membrane; 2) an increased IDO-dependent tolerogenesis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17632406
DOI: 10.1097/01.tp.0000269199.16209.22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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