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Article

Tolerogenic Phenotype of IFN-γ-Induced IDO+ Dendritic Cells Is Maintained via an Autocrine IDO-Kynurenine/AhR-IDO Loop.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2016

Li Qingsheng, Harden Jamie L, Anderson Charles D, Egilmez Nejat K

Abstract excerpt

Previous studies demonstrated that IL-12-driven antitumor activity is short-circuited by a rapid switch in dendritic cell (DC) function from immunogenic to tolerogenic activity. This process was dependent on IFN-γ and the tolerogenic phenotype was conferred by IDO. Extended monitoring of IDO(+) DC in the tumor-draining lymph nodes of IL-12 plus GM-CSF-treated tumor-bearing mice revealed that whereas IFN-γ...

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Share to Dendritic Cells
Share to Granulocyte-Macrophage Colony-Stimulating Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Indoleamine-Pyrrole 2,3,-Dioxygenase

Share to Interferon-gamma

Share to Interleukin-12

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Share to Neoplasms, Experimental

Share to Tumor Escape

Source

Identifiers

PMID: 27316681
DOI: 10.4049/jimmunol.1502615

Genes

IDO1
IDO2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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