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The Kynurenine Pathway and Cancer: Why Keep It Simple When You Can Make It Complicated

4 Jun 2022

Abstract excerpt

The kynurenine pathway has been highlighted as a gatekeeper of immune-privileged sites through its ability to generate from tryptophan a set of immunosuppressive metabolic intermediates. It additionally constitutes an important source of cellular NAD+ for the organism. Hijacking of its immunosuppressive functions, as recurrently observed in multiple cancers, facilitates immune evasion and promotes tumor...

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PMID: 35681770
DOI: 10.3390/cancers14112793

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