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Immuno-Metabolic Modulation of Liver Oncogenesis by the Tryptophan Metabolism

9 Dec 2021

Abstract excerpt

Metabolic rewiring in tumor cells is a major hallmark of oncogenesis. Some of the oncometabolites drive suppressive and tolerogenic signals from the immune system, which becomes complicit to the advent and the survival of neoplasia. Tryptophan (TRP) catabolism through the kynurenine (KYN) pathway was reported to play immunosuppressive actions across many types of cancer. Extensive debate of whether the culprit of...

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PMID: 34943977
DOI: 10.3390/cells10123469

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