Article

The Kynurenine Pathway as a Convergent Hub Linking Toll-Like Receptor Signaling, Environmental Exposures, and Gut–Brain Axis Dysfunction in Neurodegenerative Diseases

2026-08-04

Abstract excerpt

Tryptophan (Trp) metabolism plays a central role in neuroimmune communication, integrating immune, metabolic, endocrine, and neural responses. In addition to serving as a precursor for serotonin and melatonin biosynthesis, Trp is metabolized by both host cells and the gut microbiota, generating bioactive metabolites that influence gut homeostasis, immune regulation, and brain function. Approximately 95% of free Tr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4c40fb47-8ea5-5129-9dfd-3f9ea19fe1d3
DOI: 10.20944/preprints202608.0184.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Kynurenine Pathway as a Convergent Hub Linking Toll-Like Receptor Signaling, Environmental Exposures, and Gut–Brain Axis Dysfunction in Neurodegenerative DiseasesDOI 10.20944/preprints202608.0184.v1Read

Immune Influencers in Action: Metabolites and Enzymes of the Tryptophan-Kynurenine Metabolic PathwaySemantic proximity Read

Tryptophan Metabolites Along the Microbiota-Gut-Brain Axis: An Interkingdom Communication System Influencing the Gut in Health and DiseaseSemantic proximity Read

The tryptophan metabolic pathway of the microbiome and host cells in health and diseaseSemantic proximity Read

Tryptophan metabolism and the gut-brain axis: focus on specific gut microbial generaSemantic proximity Read

Tryptophan metabolism as a target in gut microbiota, ageing and kidney diseaseSemantic proximity Read

Redefining Roles: A Paradigm Shift in Tryptophan-Kynurenine Metabolism for Innovative Clinical ApplicationsSemantic proximity Read

Neuroinflammation and the Kynurenine Pathway in CNS Disease: Molecular Mechanisms and Therapeutic ImplicationsSemantic proximity Read

Microbial modulation of tryptophan metabolism links gut microbiota to disease and its treatmentSemantic proximity Read

Kynurenine Pathway of Tryptophan Metabolism in Neuropsychiatric Disorders: Pathophysiologic and Therapeutic ConsiderationsSemantic proximity Read

Tryptophan metabolite atlas uncovers organ, age, and sex-specific variationsSemantic proximity Read

Targeting the kynurenine pathway in gliomas: Insights into pathogenesis, therapeutic targets, and clinical advancesSemantic proximity Read

Aberrant Tryptophan Metabolism Manipulates Osteochondral HomeostasisSemantic proximity Read