Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Persistent infectious diseases say – IDO. Role of indoleamine-2,3-dioxygenase in disease pathogenesis and implications for therapy

23 Nov 2012

Abstract excerpt

Indoleamine-2,3-dioxygenase (IDO) is an enzyme that catabolises tryptophan - an essential amino acid critical for T cell proliferation. Initially recognized as a first line of host defense against infectious pathogens, IDO has been subsequently identified as an important immune-regulator inhibiting T-cell responses and promoting immune tolerance. Research over the past few years has demonstrated a crucial role...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bipolar Disorder and Treatment
Share to Mental Health Research Topics
Share to Tryptophan and brain disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23174025
DOI: 10.3109/1040841x.2012.742037

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Persistent infectious diseases say – IDO. Role of indoleamine-2,3-dioxygenase in disease pathogenesis and implications for therapyPMID 23174025Read ↗

The role of indoleamine 2, 3 dioxygenase in regulating host immunity to leishmania infectionSemantic proximity Read ↗

Wounding the Immune System with its Own Blade: HIV-Induced Tryptophan Catabolism and PathogenesisSemantic proximity Read ↗

Role of indoleamine 2,3-dioxygenase in health and diseaseSemantic proximity Read ↗

Indoleamine 2,3-Dioxygenase, Tryptophan Catabolism, and Mycobacterium avium subsp. paratuberculosis: a Model for Chronic Mycobacterial InfectionsSemantic proximity Read ↗

Indoleamine 2,3-Dioxygenase 2 (IDO2): The Protein That Lived TwiceSemantic proximity Read ↗

Indoleamine 2,3-Dioxygenase and Dendritic Cell TolerogenicitySemantic proximity Read ↗

IDO1 promotes CSFV replication by mediating tryptophan metabolism to inhibit NF-κB signalingSemantic proximity Read ↗

Indoleamine 2,3-dioxygenase (IDO) in inflammation and allergy toAspergillusSemantic proximity Read ↗

Dysrupted microbial tryptophan metabolism associates with SARS-CoV-2 acute inflammatory responses and long COVIDSemantic proximity Read ↗

Influence of the tryptophan-indole-IFNÎ³ axis on human genital Chlamydia trachomatis infection: role of vaginal co-infectionsSemantic proximity Read ↗

Commensal bacteria inhibit viral infections via a tryptophan metaboliteSemantic proximity Read ↗

Geographic Variability and Pathogen-Specific Considerations in the Diagnosis and Management of Chronic Granulomatous DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.