Article
Human type 1 and type 2 conventional dendritic cells express indoleamine 2,3-dioxygenase 1 with functional effects on T cell priming.
European journal of immunology - 1 Jun 2021
Sittig Simone P, van Beek Jasper J P, Flórez-Grau Georgina, Weiden Jorieke, Buschow Sonja I, van der Net Mirjam C, van Slooten Rianne, Verbeek Marcel M, Geurtz P Ben H, Textor Johannes, Figdor Carl G, de Vries I Jolanda M, Schreibelt Gerty
Abstract excerpt
Dendritic cells (DCs) are key regulators of the immune system that shape T cell responses. Regulation of T cell induction by DCs may occur via the intracellular enzyme indoleamine 2,3-dioxygenase 1 (IDO), which catalyzes conversion of the essential amino acid tryptophan into kynurenine. Here, we examined the role of IDO in human peripheral blood plasmacytoid DCs (pDCs), and type 1 and type 2 conventional DCs...
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