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Article

Indoleamine 2,3-Dioxygenase and Dendritic Cell Tolerogenicity

1 Aug 2012

Abstract excerpt

This article summarizes the molecular and cellular mechanisms that regulate the activity of indoleamine 2,3-dioxygenase (IDO), a potent immune-suppressive enzyme, in dendritic cells (DCs). Specific attention is given to differential up-regulation of IDO in distinct DC subsets, its function in immune homeostasis/autoimmunity, infection and cancer; and the associated immunological outcomes. The review will conclude...

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Identifiers

PMID: 23017144
DOI: 10.3109/08820139.2012.676122

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