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Role of indoleamine 2,3-dioxygenase in health and disease

14 Jul 2015

Abstract excerpt

IDO1 (indoleamine 2,3-dioxygenase 1) is a member of a unique class of mammalian haem dioxygenases that catalyse the oxidative catabolism of the least-abundant essential amino acid, L-Trp (L-tryptophan), along the kynurenine pathway. Significant increases in knowledge have been recently gained with respect to understanding the fundamental biochemistry of IDO1 including its catalytic reaction mechanism, the scope...

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PMID: 26186743
DOI: 10.1042/cs20140392

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