Article

Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes

2023-01-17

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan-dioxygenase (TDO) are enzymes catabolizing the essential amino acid tryptophan into kynurenine. Expression of these enzymes is frequently observed in advanced-stage cancers and is associated with poor disease prognosis and immune suppression. Mechanistically, the respective roles of tryptophan shortage and kynurenine produc...

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Literature Corpus work: 1d18141c-c776-5e7b-bca9-99a31c2306d8
DOI: 10.1101/2023.01.16.524177

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