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Article

A comprehensive analysis of TDO2 expression in immune cells and characterization of immune cell phenotype in TDO2 knockout mice.

Transgenic research - 1 Dec 2021

Li Susu, Li Siyu, Zhao Yingjie, Zhang Bingjie, Wang Xinwei, Yang Xuezhi, Wang Yueye, Jia Chengyan, Chang Yan, Wei Wei

Abstract excerpt

Tryptophan 2,3-dioxygenase (TDO2) was an initial rate-limiting enzyme of the kynurenine (Kyn) pathway in tryptophan (Trp) metabolism. We undertook this study to determine a comprehensive analysis of TDO2 expression in immune cells and assess the characterization of immune cell phenotype in TDO2 knockout mice. The expression of TDO2 in various tissues of DBA/1 mice was detected by quantitative real-time PCR (qPCR)...

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PMID: 34529208
DOI: 10.1007/s11248-021-00281-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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