HLA-DPB1 supertype-associated protection from childhood leukaemia: relationship to leukaemia karyotype and implications for prevention.

doi:10.1007/s00262-007-0349-5

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Article

HLA-DPB1 supertype-associated protection from childhood leukaemia: relationship to leukaemia karyotype and implications for prevention.

Cancer immunology, immunotherapy : CII - 1 Jan 2008

Taylor Malcolm, Harrison Christine, Eden Tim, Birch Jillian, Greaves Mel, Lightfoot Tracy, Hussain Adiba

Abstract excerpt

Most childhood B cell precursor (BCP) acute lymphoblastic leukaemia (ALL) cases carry the reciprocal translocation t(12;21)(p13;q22) ( approximately 25%), or a high hyperdiploid (HeH) karyotype (30%). The t(12;21) translocation leads to the expression of a novel fusion gene, TEL-AML1 (ETV6-RUNX1), and HeH often involves tri- and tetrasomy for chromosome 21. The presence of TEL-AML1+ and HeH cells in utero prior...

Topics

Child
Chromosome Aberrations
Core Binding Factor Alpha 2 Subunit
Female
Genetic Predisposition to Disease
HLA-DP Antigens
HLA-DP beta-Chains
Humans
In Situ Hybridization, Fluorescence
Infant, Newborn
Karyotyping
Male
Oncogene Proteins, Fusion

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Reverse Transcriptase Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 17622527
DOI: 10.1007/s00262-007-0349-5
PMCID: PMC11031005

Genes

ETV6
RUNX1

Provenance

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