Genome-wide Association Study Identifies HLA-DPB1 as a Significant Risk Factor for Severe Aplastic Anemia.

doi:10.1016/j.ajhg.2020.01.004

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Genome-wide Association Study Identifies HLA-DPB1 as a Significant Risk Factor for Severe Aplastic Anemia.

American journal of human genetics - 6 Feb 2020

Savage Sharon A, Viard Mathias, O'hUigin Colm, Zhou Weiyin, Yeager Meredith, Li Shengchao Alfred, Wang Tao, Ramsuran Veron, Vince Nicolas, Vogt Aurelie, Hicks Belynda, Burdett Laurie, Chung Charles, Dean Michael, de Andrade Kelvin C, Freedman Neal D, Berndt Sonja I, Rothman Nathaniel, Lan Qing, Cerhan James R, Slager Susan L, Zhang Yawei, Teras Lauren R, Haagenson Michael, Chanock Stephen J, Spellman Stephen R, Wang Youjin, Willis Amanda, Askar Medhat, Lee Stephanie J, Carrington Mary, Gadalla Shahinaz M

Abstract excerpt

Severe aplastic anemia (SAA) is a rare disorder characterized by hypoplastic bone marrow and progressive pancytopenia. The etiology of acquired SAA is not understood but is likely related to abnormal immune responses and environmental exposures. We conducted a genome-wide association study of individuals with SAA genetically matched to healthy controls in discovery (359 cases, 1,396 controls) and validation sets...

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Identifiers

PMID: 32004448
DOI: 10.1016/j.ajhg.2020.01.004
PMCID: PMC7010969

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