Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Strong association of the HLA-DP6 supertype with childhood leukaemia is due to a single allele, DPB1*0601.

Leukemia - 1 May 2009

Taylor G M, Hussain A, Verhage V, Thompson P D, Fergusson W D, Watkins G, Lightfoot T, Harrison C J, Birch J M

Abstract excerpt

We previously reported that susceptibility to childhood B cell precursor ALL (BCP ALL) is associated with HLA-DPB1 alleles having glutamic acid (E) rather than lysine (K) in the P4 antigenic peptide-binding pocket. Clustering approximately 90% of DPB1 alleles into DPB69E (DP2, 6, 8) and DPB69K (DP1, 3, 4) supertypes revealed that DP2 and DP8 are associated with BCP ALL, but DP6 is also associated with non-BCP...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Susceptibility
Share to Haplotypes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HLA-DP Antigens

Share to HLA-DP beta-Chains

Share to Infant, Newborn

Share to Leukemia, Myeloid, Acute

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Sequence Homology, Amino Acid

Source

Identifiers

PMID: 19148140
DOI: 10.1038/leu.2008.374

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Strong association of the HLA-DP6 supertype with childhood leukaemia is due to a single allele, DPB1*0601.PMID 19148140Read ↗

HLA-associated susceptibility to childhood B-cell precursor ALL: definition and role of HLA-DPB1 supertypes.Semantic proximity Read ↗

HLA-DPB1 supertype-associated protection from childhood leukaemia: relationship to leukaemia karyotype and implications for prevention.Semantic proximity Read ↗

Genetic susceptibility to childhood common acute lymphoblastic leukaemia is associated with polymorphic peptide-binding pocket profiles in HLA-DPB1*0201.Semantic proximity Read ↗

Genome-wide Association Study Identifies HLA-DPB1 as a Significant Risk Factor for Severe Aplastic Anemia.Semantic proximity Read ↗

Preliminary evidence of an association between HLA-DPB1*0201 and childhood common acute lymphoblastic leukaemia supports an infectious aetiology.Semantic proximity Read ↗

Transmission of HLA-DP variants from parents to children with B-cell precursor acute lymphoblastic leukemia: log-linear analysis using the case-parent design.Semantic proximity Read ↗

HLA-DP genetic variation, proxies for early life immune modulation and childhood acute lymphoblastic leukemia risk.Semantic proximity Read ↗

Characterization of a novel HLA allele, DPB1*1049:01, in a pediatric patient with severe aplastic anemia.Semantic proximity Read ↗

Five HLA-DP molecules frequently expressed in the worldwide human population share a common HLA supertypic binding specificity.Semantic proximity Read ↗

Relationship between HLA-DP supertype and survival in childhood acute lymphoblastic leukaemia: evidence for selective loss of immunological control of residual disease?Semantic proximity Read ↗

DPB1*5101--a novel DPB1*0402-related allele in west Africa affects DPB1 genotyping.Semantic proximity Read ↗

DPB1*BR: an Mhc class II DPB1 allele (DPB1*6601) of negroid origin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.