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Article

HLA-DP genetic variation, proxies for early life immune modulation and childhood acute lymphoblastic leukemia risk.

Blood - 11 Oct 2012

Urayama Kevin Y, Chokkalingam Anand P, Metayer Catherine, Ma Xiaomei, Selvin Steve, Barcellos Lisa F, Wiemels Joseph L, Wiencke John K, Taylor Malcolm, Brennan Paul, Dahl Gary V, Moonsamy Priscilla, Erlich Henry A, Trachtenberg Elizabeth, Buffler Patricia A

Abstract excerpt

The human leukocyte antigen (HLA) genes are candidate genetic susceptibility loci for childhood acute lymphoblastic leukemia (ALL). We examined the effect of HLA-DP genetic variation on risk and evaluated its potential interaction with 4 proxies for early immune modulation, including measures of infectious exposures in infancy (presence of older siblings, daycare attendance, ear infections) and breastfeeding. A...

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Identifiers

PMID: 22923493
DOI: 10.1182/blood-2012-01-404723
PMCID: PMC3471514

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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