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Article

Toward prevention of childhood ALL by early-life immune training.

Blood - 21 Oct 2021

Hauer Julia, Fischer Ute, Borkhardt Arndt

Abstract excerpt

B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most common form of childhood cancer. Chemotherapy is associated with life-long health sequelae and fails in ∼20% of cases. Thus, prevention of leukemia would be preferable to treatment. Childhood leukemia frequently starts before birth, during fetal hematopoiesis. A first genetic hit (eg, the ETV6-RUNX1 gene fusion) leads to the expansion of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34010407
DOI: 10.1182/blood.2020009895
PMCID: PMC8532195

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