Spectrum of HLA associations: the case of medically refractory pediatric acute lymphoblastic leukemia.

doi:10.1007/s00251-012-0605-5

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Article

Spectrum of HLA associations: the case of medically refractory pediatric acute lymphoblastic leukemia.

Immunogenetics - 1 Jun 2012

Klitz William, Gragert Loren, Trachtenberg Elizabeth

Abstract excerpt

Although studies of HLA and disease now date back some 50 years, a principled understanding of that relationship has been slow to emerge. Here, we examine the associations of three HLA loci with medically refractory pediatric acute lymphoblastic leukemia (pALL) patients in a case-control study involving 2,438 cases and 41,750 controls. An analysis of alleles from the class I loci, HLA-A and HLA-B, and the class...

Topics

Adolescent
Adult
Alleles
Child, Preschool
Genotype
HLA-A Antigens
HLA-B Antigens
HLA-DRB1 Chains
Haplotypes
Humans
Infections
Precursor Cell Lymphoblastic Leukemia-Lymphoma

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Identifiers

PMID: 22350167
DOI: 10.1007/s00251-012-0605-5
PMCID: PMC3349849

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