Article
Spectrum of HLA associations: the case of medically refractory pediatric acute lymphoblastic leukemia.
Immunogenetics - 1 Jun 2012
Klitz William, Gragert Loren, Trachtenberg Elizabeth
Abstract excerpt
Although studies of HLA and disease now date back some 50 years, a principled understanding of that relationship has been slow to emerge. Here, we examine the associations of three HLA loci with medically refractory pediatric acute lymphoblastic leukemia (pALL) patients in a case-control study involving 2,438 cases and 41,750 controls. An analysis of alleles from the class I loci, HLA-A and HLA-B, and the class...
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