Evidence that an HLA-DQA1-DQB1 haplotype influences susceptibility to childhood common acute lymphoblastic leukaemia in boys provides further support for an infection-related aetiology.

doi:10.1038/bjc.1998.540

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Article

Evidence that an HLA-DQA1-DQB1 haplotype influences susceptibility to childhood common acute lymphoblastic leukaemia in boys provides further support for an infection-related aetiology.

British journal of cancer - 1 Sept 1998

Taylor G M, Dearden S, Payne N, Ayres M, Gokhale D A, Birch J M, Blair V, Stevens R F, Will A M, Eden O B

Abstract excerpt

Comparison of DQA1 and DQB1 alleles in 60 children with common acute lymphoblastic leukaemia (c-ALL) and 78 newborn infant control subjects revealed that male but not female patients had a higher frequency of DQA1*0101/*0104 and DQB1*0501 than appropriate control subjects. The results suggest a m...

Topics

Alleles
Antigen Presentation
Child
Child, Preschool
Communicable Diseases
DNA
Disease Susceptibility
Female
Gene Frequency
Genetic Predisposition to Disease
HLA-DQ Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HLA-DQ alpha-Chains

HLA-DQ beta-Chains

Haplotypes

Humans

Infant

Male

Polymorphism, Single-Stranded Conformational

Source

Open in PubMed Open full text

Identifiers

PMID: 9744491
DOI: 10.1038/bjc.1998.540
PMCID: PMC2063058

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9744491-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Evidence that an HLA-DQA1-DQB1 haplotype influences susceptibility to childhood common acute lymphoblastic leukaemia in boys provides further support for an infection-related aetiology.PMID 9744491Read ↗

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