Article
Genetic susceptibility to childhood common acute lymphoblastic leukaemia is associated with polymorphic peptide-binding pocket profiles in HLA-DPB1*0201.
Human molecular genetics - 1 Jul 2002
Taylor G Malcolm, Dearden Simon, Ravetto Paul, Ayres Michelle, Watson Pamela, Hussain Adiba, Greaves Mel, Alexander Freda, Eden Osborn B
Abstract excerpt
In a previous study, we obtained preliminary evidence in a small series of patients (n = 63) suggesting that susceptibility to childhood common acute lymphoblastic leukaemia (c-ALL) was associated with an allele at the HLA-DPB1 locus, DPB1*0201. We have now tested this hypothesis by comparing the frequency of children with leukaemia (n = 982) who typed for specific DPB1 alleles and two groups of non-leukaemic...
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