Article
Relationship between HLA-DP supertype and survival in childhood acute lymphoblastic leukaemia: evidence for selective loss of immunological control of residual disease?
British journal of haematology - 1 Apr 2009
Taylor G Malcolm, Richards Sue, Wade Rachel, Hussain Adiba, Simpson Jill, Hill Frank, Mitchell Chris, Eden Tim
Abstract excerpt
We recently reported that two of six HLA-DP supertypes (DP1-4, 6, 8) were associated with susceptibility (DP2) and resistance (DP1) to childhood acute lymphoblastic leukaemia (ALL). To determine whether DP supertypes are associated with childhood ALL prognosis, we compared treatment outcomes in a cohort (n = 798) of DPB1-typed ALL cases in the UK Medical Research Council UKALL XI trial. No differences in clinical...
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